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Digital Image Analysis has an Additive Beneficial Role to Conventional Cytology in Diagnosing the Nature of Biliary Ducts Stricture

مؤلف البحث
AhmedHelmy
Heba MohamedSaad Eldien
Adnan AhmedMohammed
Gehan SayedSeifeldein
Ahmed MohammedAbu-Elfatth
مجلة البحث
Journal of Clinical and Experimental Hepatology

المشارك في البحث
الناشر
Elsevier
تصنيف البحث
1
عدد البحث
https://doi.org/10.1016/j.jceh.2020.07.009
موقع البحث
https://www.sciencedirect.com/science/article/pii/S0973688320301092?casa_token=WyhAMHGJGBEAAAAA:Sxqp8WCKAISkkFLI4GniGslVoH3YgGfncEiP4XsLzbCUC_5hSl2KOdPtFGthrrwY40x7S8HdxQ
سنة البحث
2020
صفحات البحث
10
ملخص البحث

Background & Aim
Conventional cytological evaluation (CCE) fails to identify nature indeterminate biliary duct stricture (IBDS) in many cases. Digital image analysis (DIA) has the ability to identify and analyze the DNA content of cells. This study assesses the role of DIA in recognizing the nature of IBDS compared to CCE.

Methods
A prospective observational study was conducted at the Al-Rajhi University Hospital. Fifty patients with IBDS, based on abdominal imaging, were subjected to endoscopic retrograde cholangiopancreatography (ERCP) and brush sampling. These samples were evaluated with CCE and DIA. Follow-up for at least 9 months and cost-analysis had also been done.

Results
Based on the final diagnosis, 32 (64.0%) patients had malignant stricture, and 39 (78.0%) had distal stricture. DIA had 84.40% (95% CI; 67.20–94.70) sensitivity and 94.40% (95% CI; 72.70–99.90) specificity in identifying nature of IBDS, whereas CCE had 19.0% (95% CI; 7.20–36.40) sensitivity and 89.0% (95% CI; 65.30–98.60) specificity. Combination of both modalities had 84.40% (95% CI; 67.20–94.70) sensitivity and 83.30% (95% CI; 58.60–96.40) specificity in identification nature of IBDS. Based on CCE alone, only 6/32 (18.80%) of malignant stricture were diagnosed, and 26/32 (81.20%) were missed. However, DIA alone was able to diagnose 27/32 (84.40%) of malignant stricture, and only 5 cases were missed. Both procedures had detection rate of malignant stricture as DIA alone. Benign stricture was correctly diagnosed in 16/18 (88.80%), 17/18 (94.40%), and 15/18 (83.30%) using CCE alone, DIA alone, and both procedures together, respectively. Cost per detection additional one malignant stricture using DIA required 99.4$.