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Efficacy of adipose-derived stromal vascular fraction cells in the management of chronic ulcers: a randomized clinical trial

مؤلف البحث
Emil Tanios, Tohamy M Ahmed, Engy A Shafik, Mahmoud Farouk Sherif, Douaa Sayed, Noha Gaber & Youssef Hassan
تاريخ البحث
مجلة البحث
REGENERATIVE MEDICINE
عدد البحث
VOL. 16, NO. 11
سنة البحث
2021
ملخص البحث

Background: Cell therapy is a promising method for improving healing in chronic ulcers through delivery of isolated adipose-derived stromal vascular fraction. Objectives: This study investigates the autologous stem cell yield of adipose tissue and its efficacy in chronic ulcers compared with conventional methods. Methods: This study was a randomized controlled trial. After the study design and protocol were established and ethical committee approval was obtained, we enrolled 100 patients divided into study and control groups. In the study group, we performed debridement and autologous stem cell injection every 3 weeks. The control group was treated with debridement and conventional dressing. Assessments included clinical and histological parameters. Results: The study group showed improved healing. Conclusion: Using autologous adipose-derived stromal vascular fraction cells is an effective treatment method for chronic ulcers.