Background The importance of uric acid has been increasingly appreciated because of its association with the development of diabetes mellitus and related diseases, and with the increasing incidence of diabetes, studying the impact of hyperuricemia in patients with diabetes type 2 is necessary. So we aimed to measure serum uric acid (SUA) levels in patients with diabetes type 2 and to assess the relation between the estimated glomerular fltration rate (eGFR) and the SUA in patients with type 2 diabetes (T2DM). Subjects and methods This study is a cross-sectional conducted on 142 adult patients who attended the Outpatients Diabetes Clinic and Endocrinology Center in the Department of Internal Medicine, Assiut University Hospitals, in the period from the 1st of November 2021 up to October 2022. We measured serum uric acid level, serum creatinine, cholesterol, low- and high-density lipoproteins, triglycerides, and eGFR. Results Overall, 142 patients were enrolled in the study; all patients had type 2 diabetes. The mean age of the participants was 61.08±9.73 years. Based on SUA level, 46 (32.4%) patients had normal SUA and 96 (67.6%) patients had high SUA. Sixty-nine (48.6%) patients had normal eGFR and 73 (51.4%) patients had reduced eGFR. We found that serum uric acid had a positive signifcant correlation with the number of metabolic syndrome criteria, cholesterol, low-density lipoproteins, and triglycerides. Meanwhile, it had a negative signifcant correlation with eGFR and highdensity lipoproteins. Conclusion Serum uric acid was strongly associated with metabolic syndrome components and reduced eGFR in patients with T2DM. Keywords Serum uric acid level, Type 2 diabetes, Metabolic syndrome