Under earthquake excitations, reinforced concrete (RC) columns could be subjected to lateral drift reversals and a combination of axial forces, bending moments, and torsional effects. This paper investigates the behavior of glass fiber-reinforced polymer (GFRP)-RC columns under seismic-simulated loading, including torsion, which has not been studied previously. Seven large-scale circular GFRP-RC column-footing connections were cast and tested under various combined reversed cyclic loading configurations to examine the effects of torsion-bending moment ratio (tm), transverse reinforcement ratio, and concrete compressive strength. The test results revealed that increasing the tm reduced the lateral load capacity and deformability of the GFRP-RC column, but resulted in a more symmetric torque-twist relationship. Increasing the transverse reinforcement ratio mitigated core damage and provided additional support (for example, spiral turns) for torsion-induced tensile stresses. Moreover, increased concrete compressive strength bolstered torque capacity and torsional stiffness, while, under a tm of 0.4, it resulted in decreased twist capacity. When torsion was present, increasing the concrete compressive strength had an insignificant impact on the bending-shear response, differing from findings for GFRP-RC columns subjected to seismic loading without torsion.