COVID-19 pandemic is a major worldwide health disaster
firstly reported in December 2019. The Food and Drug
Administration (FDA) has offered the public hope of
halting it, authorizing vaccinations for emergency use with
more than 85% efficacy against serious acute respiratory
syndrome (SARS-CoV-2). Recent outbreaks of SARS-CoV-2
variations including spike-protein mutations, the key
vaccines viral target for immune response, have prompted
a thorough investigation into the vaccine's long-term
effectiveness. Consequently, this review assayed the
details on SARS-CoV-2 infection mechanism and how to
control the infection by different types of SARS-CoV-2
vaccines, and their effectiveness against other mutant
strains. Additionally, the review summarized the different
complaints which have been recorded after vaccination. In
conclusion, these negative effects must be constantly
weighed against the predicted advantages in terms of
disease prevention. Although COVID-19 vaccination is
recommended for everyone aged 5 years and older, SARS-
CoV-2 is high likely to continue to be a pandemic
infectious as a result of the broadcasting of variants of th