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Synergistic effects of quercetin-loaded CoFe2O4@Liposomes regulate DNA damage and apoptosis in MCF-7 cancer cells: based on biophysical magnetic hyperthermia

Research Authors
Shehab Elbeltagi, Abo bakr Abdel shakor, Hanan M. Alharbi, Hesham M Tawfeek, Basmah N Aldosari, Zienab E. Eldin, Basma H Amin, Mohamed Abd El-Aal
Research Abstract

Breast cancer (BC) is the most common malignancy in women globally. Significant progress has been made in developing structural nanoparticles (NPs) and formulations for targeted smart drug delivery (SDD) of pharmaceuticals, improving the precision of tumor cell targeting in therapy.

Significance

Magnetic hyperthermia (MHT) treatment using magneto-liposomes (MLs) has emerged as a promising adjuvant cancer therapy.

Methods

CoFe2O4 magnetic NPs (MNPs) were conjugated with nanoliposomes to form MLs, and the anticancer drug quercetin (Que) was loaded into MLs, forming Que-MLs composites for antitumor approach. The aim was to prepare Que-MLs for DD systems (DDS) under an alternating magnetic field (AMF), termed chemotherapy/hyperthermia (chemo-HT) techniques. The encapsulation efficiency (EE), drug loading capacity (DL), and drug release (DR) of Que and Que-MLs were …

Research Date
Research Department
Research Journal
Drug Development and Industrial Pharmacy
Research Publisher
Drug Development and Industrial Pharmacy
Research Vol
Volume 50, Issue 6
Research Website
https://scholar.google.com.eg/scholar?oi=bibs&cluster=6719934720188533599&btnI=1&hl=en
Research Year
2024
Research Pages
561-575