As the demand for energy continues to rise, it becomes increasingly crucial to explore new energy resources and enhance the efficiency of existing ones. Combined Cycle Power Plants (CCPPs) play a pivotal role in improving efficiency and electricity generation. However, conducting a comprehensive performance analysis is essential to maintain optimal operating conditions. This paper presents a case study involving energy and exergy analyses of a 750 MW CCPP located in Assiut, Egypt. The study's primary objective is to assess the energy efficiency of the plant and identify opportunities for enhancement. The findings indicate that the combustion chambers are the primary contributors to exergy destruction, accounting for 53.3% of the total exergy loss, followed by heat recovery steam generators (HRSGs) at 32%, compressors at 5.3%, steam turbines at 5%, gas turbines at 2.3%, and cooling systems at 1.7%. Additionally, the research highlights that the energy and exergy efficiencies for the entire plant stand at 33.5% and 34.6%, respectively.