This paper documents the testing of six 20 ft × 4 ft × 8 in. (6.1 m × 1.2 m × 203.2 mm) precast, prestressed concrete sandwich panels constructed with continuous rigid insulation and a carbon-fiber-reinforced polymer grid shear transfer mechanism. All panels were identical except for foam type and were cast together on the same prestressing bed. Three of the six panels were fabricated with expanded polystyrene (EPS) foam insulation, and the remaining three panels were fabricated using sandblasted extruded polystyrene (XPS) foam. For each group of three panels, one was tested to failure as a control and two others were cycled 2 million times to 45% of their design ultimate load before failure testing. The tested EPS panels all failed when the applied lateral load was greater than or equal to 100 lb/ft² (4.79 kPa), which is 2.35 times their design load of 42.5 lb/ft² (2.03 kPa). The tested XPS panels all failed at the equivalent of 175 lb/ft² (8.38 kPa) of applied lateral pressure, which is more than 4.0 times their design load of 42.5 lb/ft². All four panels subjected to fatigue survived 2 million lateral load cycles without any visible signs of degradation.