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Carbazoles: Role and Functions in Fighting Diabetes

Research Authors
Fedora Grande, Giuseppina Ioele, Anna Caruso, Maria Occhiuzzi, Hussein El-Kashef, Carmela Saturnino, and Maria Stefania Sinicropi
Research Abstract

Carbazole derivatives have gained a lot of attention in medicinal chemistry over the last few decades due to their wide range of biological and pharmacological properties, including antibacterial, antitumor, antioxidant, and anti-inflammatory activities. The therapeutic potential of natural, semi-synthetic or synthetic carbazole-containing molecules has expanded considerably owing to their role in the pathogenesis and development of diabetes. Several studies have demonstrated the ability of carbazole derivatives to reduce oxidative stress, block adrenergic hyperactivation, prevent damage to pancreatic cells and modulate carbohydrate metabolism. In this survey, we summarize the latest advances in the synthetic and natural carbazole-containing compounds involved in diabetes pathways.

Research Date
Research Department
Research Journal
Applied Sciences
Research Year
2023