Impact of duloxetine on succinylcholine‐induced postoperative myalgia after direct microlaryngoscopic surgeries: Randomized controlled double‐blind study

Faculty of Medicine

Assiut University

Impact of duloxetine on succinylcholine‐induced postoperative myalgia after direct microlaryngoscopic surgeries: Randomized controlled double‐blind study

Research Authors
Mohamed F Mostafa, Osama Ali Ibraheim, Ahmed K Ibrahim, Reham AE Ibrahim, Ragaa Herdan
Research Date
Research Department
Department of  Anesthesia and Intensive Care
Research Journal
Pain Practice
Research Member
Mohamed Fathy Mostafa Morsy
Raja Ahmad Abdullah Mohamed
Reham Abdel-Wakil Ibrahim Mohamed
Ahmed Mohamed Khair Shabib Ibrahim
Osama Ali Mohamed Ibrahim
Research Year
2021
Research Abstract

Succinylcholine is a preferred muscle relaxant for rapid sequence intubation. Postoperative myalgia (POM) is one of its commonest adverse effects with unknown pathogenesis. Various modalities were examined to reduce POM. We hypothesized that duloxetine may reduce incidence and severity of fasciculation or succinylcholine‐induced POM in outpatient surgeries.

METHODS

This randomized double‐blinded trial involved controlled 70 adult participants scheduled for elective direct microlaryngoscopic surgeries. Before induction of general anesthesia by 2 hours, 35 patients received duloxetine 30mg orally (Group‐D) and 35 patients received similar oral starch placebo capsules (Group‐C). Fasciculations, POM, sedation score, time to first rescue analgesia, total analgesic consumption 24 hours after surgery, patients’ satisfaction, and adverse effects were recorded.