Introduction:Quality of life (QOL) is described as an individual's perception of their current state of affairs in relation to the cultural framework. Congenital heart disease (CHD) assessment will yield important data for identifying risk groups and developing intervention strategies that concentrate on the needs of these children's health. 
Aim of the study: to evaluate the quality of life in children with CHD in patients attending Assiut University Children Hospital and Cardiology Department.
Patients and methods: This study was analytic cross-sectional study, performed at Pediatric Cardiology Outpatient Clinic and Inpatient Pediatric Cardiology Unit in Assuit University Hospital over one year from 1^st January 2020 to 31^st December 2020 (one year study).It included 55 children (2:18 years) who were diagnosed as having heart disease. Results:The most common type of congenital cyanotic heart disease (HD) was tetralogy of Fallot then transposition of great arteries (TGA). Acyanotic HD were divided into two groups; congenital and acquired. The most common congenital acyanotic HD was ventricular septal defect (VSD) and the most common acquired acyanotic HD was rheumatic HD. All patients were assessed by using the Arabic version of the Pediatric qualify of life inventory (PedsQL). There were many cognitive and communication problems in both cyanotic and acyanotic patients.
Conclusion: Children with congenital heart disease (either cyanotic or acyanotic) are at risk of having lower quality of life, which is a common problem in CHD children.