Introduction: Gastric variceal bleeding is a serious cause of morbidity and mortality among portal hypertension (PH) patients. The exact frequency of gastric varices (GV) and risk factors for bleeding among Upper Egypt patients are not fully estimated. Aim of the work: to estimate the frequency and the possible risk factors for bleeding from gastric varices in Upper Egypt patients. Patients and Methods: We analyzed case records of 1520 patients with portal hypertension (PH), who admitted to Gastroenterology Department at Assuit University Hospital and underwent upper endoscopy during the last two years. Results: GV were seen in 28.5% of patients with PH (433/1520) and were the source of bleeding in 17.6% of patients. The frequencies of gastroesophageal varices type 1 (GOV1), gastroesophageal varices type 2 (GOV2) and isolated gastric varices type 1 (IGV1) were 17.9%, 6.5% and 4.1% of patients; respectively. GOV1, GOV2 and IGV1 were the source of bleeding in 9%, 4.6% and 4% of patients; respectively. In univariate analysis, red color signs (RCS), large gastric varices (F3) and severe liver dysfunction (Child-Pugh class B and C) were significant risk factors for IGV1bleeding (P-value: 0.0001, 0.001, 0.01; respectively). By multivariate logistic regression; RCS and severe liver dysfunction (Child-Pugh class B and C) were independent risk factors for bleeding from GV (Odd's ratio 99 and 17; respectively and P-value 0.0001 and 0.002; respectively). Conclusion: Bleeding from GV is more frequent with the presence of RCS, large GV and severe liver dysfunction. The presence of RCS and severe liver dysfunction are independent risk factors for bleeding from GV.