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Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate
the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case–control study included 20 children
with JIA as well as 20 healthy children with matching age and sex as a control group. All patients included in the study were
in activity as determined by visual analog scale. In addition to complete clinical evaluation, basic investigations, peripheral
blood B and T lymphocyte subpopulations were done to all participants by fow cytometry. JIA patients displayed a signifcant decrease in IgM memory B lymphocytes, switched memory B lymphocytes, and total memory B lymphocytes when
compared to the healthy controls. The percentages of naïve B lymphocytes were signifcantly increased in JIA patients than
in controls. Total T lymphocytes, CD8+CD28null cells, and CD4+CD28null cells were signifcantly increased in JIA patients
as compared to controls. In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition
of memory cells which may have a role in sustaining the JIA disease activity.
Research Department
Research Journal
Arch Immunol Ther Exp (Warsz). 2019 Sep 18. doi: 10.1007/s00005-019-00560-7. [Epub ahead of print]
Research Member
Research Publisher
springer
Research Rank
1
Research Vol
Archivum Immunologiae et Therapiae Experimentalis.ISSN: 0004-069X (Print) 1661-4917 (Online) Volume 67
Research Website
NULL
Research Year
2019
Research_Pages
pp 1–6
Research Abstract
