Elevated hippocampal mGlut2 receptors in rats with metabolic syndrome-induced-memory impairment, possible protection by vitamin D.

Faculty of Medicine

Assiut University

Elevated hippocampal mGlut2 receptors in rats with metabolic syndrome-induced-memory impairment, possible protection by vitamin D.

Research Authors
Enas A. Hamed. Zienab Alrefaie, Soad S. Ali
Research Date
Research Department
Department of Medical Physiology
Research Journal
Brain Research Bulletin
Research Member
Enas Ahmed Hamed Omran
Research Vol
180
Research Year
2022
Research_Pages
108-117
Research Abstract

Background

Metabolic syndrome patients are commonly prone to major health problems as cardiovascular diseases, diabetes mellitus, chronic kidney disease, cancer and neuropsychological complications including dementia.

Objectives

This research investigates mechanisms linking metabolic syndrome to cognitive impairment and possible impact of vitamin D supplementation.

Methods

Forty male Wistar rats were divided into 4 groups. Control, metabolic syndrome (20% fructose solution in drinking water for 12 weeks, vitamin D supplemented (500 IU/kg/day) and metabolic syndrome supplemented with vitamin D. Animals were assessed for spatial memory, hippocampal expression of SNAP 25, VAMP and mGlut2 receptor and hippocampus histological examination. Animals with metabolic syndrome showed prolonged acquisition and retention latencies in morris water maze, decreased hippocampal expression of …