Epidemiology, Risk factors, Outcomes and role of Serpin A3 as a biomarker for Transition of Acute Kidney Injury to Chronic Kidney Disease in critically ill patients

Faculty of Medicine

Assiut University

Epidemiology, Risk factors, Outcomes and role of Serpin A3 as a biomarker for Transition of Acute Kidney Injury to Chronic Kidney Disease in critically ill patients

Research Authors
Marwa K Khairallah, Asma A. Gaber, Mohammed H Maghraby, Marwa A dahpy, Simran Singh Parmer, Mohammed H Mostafa
Research Date
Research Department
Internal Medicine
Research Journal
Egyptian journal of internal medicine
Research Member
Asmaa Abd Elshafy Mohamed
Marwa Khairallah
Mohamed Hossam El-Din/ Hassan Mohamed Maghraby
Mohamed Hasan Mostafa Abdellah
Marwa Abdel Hafiz Abdel Aal Hassan
Research Year
2024
Research Abstract

Several studies have suggested a causal link between acute kidney injury and the consequent development of chronic kidney disease. The severity, frequency, and duration of acute injury are key factors in this process.

Aims

This study aimed to determine the epidemiology and outcomes of AKI to CKD transition in critically ill adult patients and to study the role of Serpin-A3 in the early recognition of AKI to CKD transition.

Methods

In this prospective observational study, a total of 252 patients attending Assiut University Hospitals Critical Care Unit and developed AKI during their stay were recruited. Serum and urinary Serpin A3 were measured by ELISA Kit. Complete blood picture, kidney function tests, urine analysis, serum electrolytes (serum sodium, potassium, calcium, phosphorus, and magnesium), liver function test, coagulation profile, C-reactive protein, 24-h urinary protein or urinary albumin/creatinine …