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Detection of Anti-Fasciola isotypes among patients with Fasciolasis befor and after treatment with Mirazid
J.of Egyptian Society of Parasitology,vol.(34)No.(3) Dec. 2004

Research Authors
ahmed diab, mohsean hasan , mohamed abdelghafar, osama hasnona elsaed elbadraway , ahmed saleah osam haber and moetaz dawood
Research Department
Research Journal
J.of Egyptian Society of Parasitology,vol.(34)No.(3) Dec. 2004
Research Member
Research Publisher
NULL
Research Rank
1
Research Vol
(34)No.(3) Dec. 2004
Research Website
NULL
Research Year
2002
Research_Pages
(34)No.(3) Dec. 2004
Research Abstract

Abstract
Stool examination using modified Kato thick smear method was performed to detect Fasciola eggs and other parasites. Abdominal pain was the major presenting symptom (87.7%) followed by pallor (83.3%) and fever (16.7%). Anaemia and hepatomegaly were recorded in 77.7% of patients compared to 27.7% with splenomegaly. Abdominal ultrasonography revealed hepatomegaly and common bile duct dilatation in 77.7% of patients. Moreover, 5 cases showed diagnostic. Olympic game rings All patients had positive IgG4 levels, 55 cases were positive for specific total IgG and IgG1, whereas, only 24 cases had positive IgG2 levels (26.6%). All negative control group showed no cross reactions. On the other hand, ELISA detecting IgG4 showed the highest specificity (95%), followed by IgG2 (85%) and the least specific test was obtained with detection of IgG (70%) and IgG1 (65%). One month after treatment, 91.1% of patients (82/90) were completely cured and even after another two months follow-up. In completely cured patients none of anti-Fasciola isotypes was significantly changed. So, detection of anti-Fasciola isotypes especially IgG4 is very specific for the accurate diagnosis of human fascioliasis.