Detection of multiple extensively-drug resistant hypervirulent Klebsiella pneumoniae clones from patients with ventilator-associated pneumonia egypt

Faculty of Medicine

Assiut University

Detection of multiple extensively-drug resistant hypervirulent Klebsiella pneumoniae clones from patients with ventilator-associated pneumonia egypt

Research Authors
Hadeel Elzeny1​, Wegdan Mohamed2​, Enas Daef2​, Omnia El-Badawy2​, Lamiaa Shaaban3​, Naglaa S. Osman4​, Safy Hadiya1​ and Sherine Aly2​ORCID icon
Research Date
Research Department
Department of Microbiology and Immunology
Research Journal
Journal of Medical Microbiology
Research Member
Sherine Ahmed Abdel-Rahman Ali
Wijdan Abdel-Hamid Mohamed Bakhit
Enas Abdel-Majid Mohamed Sayed Daef
Omnia Hasan Bakr Badawy
Lamia Hasan Shaaban Hasan
Naglaa Samy Mohamed Osman
Research Publisher
Microbiology Society
Research Vol
Volume 72, Issue 6
Research Website
https://scholar.google.com.eg/scholar?oi=bibs&cluster=13956000809166275176&btnI=1&hl=en
Research Year
2023
Research_Pages
001701
Research Abstract

Introduction. Hypervirulent-K. pneumoniae (hvKP) is an evolving pathotype that is more virulent than the classical-K. pneumoniae (cKP) and causes serious fatal illnesses.

Hypothesis/Gap Statement. Although there are few reports on hvKP isolated from Egyptian patients, the molecular characteristics and clonal relatedness of MDR-hvKP have not been adequately investigated.

Aim. To investigate the microbiological and genetic characteristics as well as the epidemiology of hvKP induced ventilator-associated pneumonia (VAP).

Methodology. A retrospective study of 59 K. pneumoniae inducing VAP was conducted at Assiut University Hospitals from November 2017 to January 2019. All K. pneumoniae were tested for resistance phenotype, capsular genotype (K1 and K2), virulence gene profile (c-rmpA, p-rmpA, iucA, kfu, iroB, iroN), and the presence of resistance genes (blaNDM-1, blaCTX-M-3-like, blaCTX-M-14-like …