Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Medicinal Chemistry

Researches

Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products.

The research focuses on the following strategic Research Themes:

  • Design and synthesis of new chemical entities.
  • Computer aided drug design studies.
  • Structure-Activity relationship studies.
  • Combinatorial chemistry.
  • Prod rugs developments.
  • Analytical methods for bioavailability and metabolic studies.

Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

 

 

# Title Research Year
11 In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations 2022
12 Phytochemical investigation, molecular docking studies and DFT calculations on the antidiabetic and cytotoxic activities of Gmelina philippensis CHAM. 2022
13 New Cell Cycle Checkpoint Pathways Regulators with 2-Oxo-indoline Scaffold as Potential Anticancer Agents: Design, Synthesis, Biological Activities and In Silico Studies 2022
14 Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages 2022
15 Novel Azine Linked Hybrids of 2-indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies 2022
16 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
17 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
18 Lipophilicity study of different cephalosporins: Computational prediction of minimum inhibitory concentration using salting-out chromatography 2021
19 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
20 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021