Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Medicinal Chemistry

Researches

Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products.

The research focuses on the following strategic Research Themes:

  • Design and synthesis of new chemical entities.
  • Computer aided drug design studies.
  • Structure-Activity relationship studies.
  • Combinatorial chemistry.
  • Prod rugs developments.
  • Analytical methods for bioavailability and metabolic studies.

Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

 

 

# Title Research Year
1 Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies 2024
2 Computational Design of Azine-Linked Hybrids of 2-Indolinone-Thiazolodine Scaffold as Novel and Promising Quorum Sensing Inhibitors 2024
3 Thiadiazine-2-thione derivatives as new cell- cycle inhibitors 2023
4 Combined experimental/computational aspects for the molecular interaction of empagliflozin with bovine serum albumin: Quantification and application to human plasma 2023
5 Thiadiazine-2-thione Derivatives as New Carrier Systems for Isothiocyanates and Dithiocarbamic acid with Potential Anticancer Activities 2023
6 Phytochemical investigation, molecular docking studies and DFT calculations on the antidiabetic and cytotoxic activities of Gmelina philippensis CHAM. 2022
7 New Cell Cycle Checkpoint Pathways Regulators with 2-Oxo-indoline Scaffold as Potential Anticancer Agents: Design, Synthesis, Biological Activities and In Silico Studies 2022
8 Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages 2022
9 Novel Azine Linked Hybrids of 2-indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies 2022
10 Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives 2022