Department Researches & Publications

Faculty of Pharmacy

Assiut University

Department of Medicinal Chemistry

Researches

Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products.

The research focuses on the following strategic Research Themes:

  • Design and synthesis of new chemical entities.
  • Computer aided drug design studies.
  • Structure-Activity relationship studies.
  • Combinatorial chemistry.
  • Prod rugs developments.
  • Analytical methods for bioavailability and metabolic studies.

Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

 

 

# Title Research Year
11 Novel Spiro Hybrids of 2-indolinone and Thiazolodinone Scaffolds as Cell Cycle Checkpoints’ Pathways Regulators with potential anticancer activity 2022
12 New Insights into the Structural Requirements of Isatin-Derived Pro-Apoptotic Agents against Acute Myeloid Leukemia 2022
13 Structure Based Design of Novel Azine Linked Hybrids of 2-Indolinone- Thiazolodine Scaffold as Potential Quorum Sensing Inhibitors for Fighting Antimicrobial Resistance 2022
14 Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1, 2, 3-triazole-4-yl derivatives as topoisomerase II inhibitors 2022
15 In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations 2022
16 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
17 Crystal structure and quantum chemical calculations of (E)1-benzyl-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one 2021
18 Novel 2-Indolinone Based derivatives Targeting Cell Cycle Checkpoint’s Proteins as Potential Anticancer Agents 2021
19 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
20 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021