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Ingenines A and B, two new alkaloids from the Indonesian sponge Acanthostrongylophora ingens

Research Authors
Sabrin RM Ibrahim, Gamal A Mohamed, Mohamed F Zayed and Hanaa M Sayed
Research Department
Research Journal
Drug Research, DOI: 10.1055/s-0034-1384577
Research Publisher
Thieme
Research Rank
1
Research Vol
Vol. 65, No. 7
Research Website
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1384577
Research Year
2015
Research Abstract

As a continuation of the work on EtOAc fraction of the Indonesian sponge Acanthostrongylophora ingens, 2 new alkaloids: one pyrimidine-β-carboline alkaloid named ingenine A (2) and one pyrimidine-γ-carboline alkaloid named ingenine B (3), along with annomontine (1) were isolated. Their structures were unambiguously established on the basis of NMR spectroscopy (1 H, 13C, 1 H-1 H COSY, HMQC, and HMBC) and mass spectral data. This is the first report of isolation pyrimidine-γ-carboline alkaloid from natural source. Compounds 1 and 3 showed pronounced cytotoxicity against the murine lymphoma L5178Y cancer cell line with ED50 7.8 and 9.1 μg/mL respectively, while compound 2 showed weak activity.