Meeting of the (Postgraduate Studies and Research) Committee at the Faculty of Pharmacy This will take place on Thursday, April 9, 2026, at 11:00 AM

    God willing, the meeting of the Graduate Studies and Research Committee and This will take place on Thursday, April 9, 2026, at 11:00 AM

And that in the office of the Prof. Dr. / Vice Dean for Graduate Studies and Research Affairs.

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Meeting of the Council of the Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy This will take place on Tuesday, April 7, 2026.

God willing, The Pharmaceutical Analytical Chemistry Department Council will hold its regular monthly meeting No. (537) This will take place on Tuesday, April 7, 2026., at 11:00 AM 

 In the meetings Hall of the Department

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Design, synthesis, apoptotic antiproliferative, and antioxidant activities of a new series of 2-mercaptobenzimidazole/3-cyanopyridin-2-one hybrids as dual EGFR/BRAFV600E inhibitors

Research Abstract

A novel series of 2-mercaptobenzimidazole-based 3-cyanopyridin-2-one hybrids (7a–l) was designed and synthesized
as potential dual inhibitors of EGFR and BRAFV600E kinases. The antiproliferative activity was evaluated
against four human cancer cell lines (MCF-7, A-549, HT-29, and Panc-1) and a normal epithelial cell line (MCF-
10A). Compound 7c exhibited the highest potency (GI₅₀ = 6 μM) and was comparably effective to the reference
doxorubicin (GI50 = 5 μM) against the four cancer cell lines analyzed. Compound 7c also showed potent EGFR
(IC₅₀ = 0.12 μM) and BRAFV600E (IC₅₀ = 0.05 μM) inhibition, induced apoptosis via caspase-3/8/9 activation,
modulated Bax/Bcl-2 expression, and demonstrated strong antioxidant activity. Molecular docking, molecular
dynamics (MD) simulations, and DFT analyses revealed key pharmacophoric interactions within the ATP-binding
sites of EGFR and BRAFV600E kinases, while in silico ADME predictions supported drug-likeness and showed no
PAINS/Brenk structural alerts; however, these predictions do not establish safety, and experimental toxicology
will be required. These findings identify compound 7c as a promising dual-target lead candidate for further
optimization in anticancer drug development.

Research Authors
Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Bahaa G.M. Youssif, Stefan Brase, Mohamed Hisham
Research Date
Research Department
Department of Pharmaceutical Organic Chemistry
Research Journal
Bioorganic Chemistry
Research Member
Bahaa Gamal Al-Din Mohammad Yousef
Research Pages
109329
Research Publisher
Science direct
Research Rank
Pharmaceutical Chemistry, Q1
Research Vol
168
Research Year
2025

The Scientific Conference of Pharmaceutics Department, Faculty of Pharmacy on Sunday, April 6, 2024.

The  Pharmaceutics Department  will hold its Scientific Conference This is on Monday, April 6, 2026, at 10:30 (AM). in the department board on the third floor under the chairmanship of the Faculty to discuss the topics that we will inform you later..

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Meeting of the Council of the Pharmaceutics Department, Faculty of This will take place on Monday, April 6, 2026, at 10:00 A.M

God willing, the meeting of the Pharmaceutics Department Board of the Faculty of Pharmacy No. (549), at the Faculty of Pharmacy, on Monday, April 6, 2026, at 10:00 A.M

in the department board on the third floor under the chairmanship of the Faculty to discuss the topics that we will inform you later.

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The Department of Medicinal Chemistry cordially invites you to attend a Scientific Seminar presented by Ms. Gehad abdelhady Ali Ahmed (Demonstrator at the Department)."

The Department of Medicinal Chemistry is pleased to invite you to a Scientific Seminar as part of its lecture and seminar program for the academic year 2025/2026.

Seminar Title:

"Ligand based Design and synthesis of potentially bioactive 3-spiro-2-oxo-2,3-dihydroindole scaffolds"

Presented by: Pharmacist Gehad abdelhady Ali Ahmed

Demonstrator at the Department of Medicinal Chemistry.

  • Date: Sunday, April 5, 2026.

  • Time: 11:00 AM.

  • Venue: Library of the Department of Medicinal Chemistry – Faculty of Pharmacy.

 

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