Background: Work addiction is characterized by a compulsive drive to work excessively, often leading to diminished job satisfaction and negatively impacting professional quality of life and creativity. Critical care nurses require a creative mindset to deal with the variety of obstacles encountered during their work. Creativity is essential for succeeding as a critical care nurse in today's competitive world. Furthermore, creativity is crucial to healthcare organizations aiming to achieve excellence and development, particularly in the context of global growth, high demands, and a limited supply of human resources. Aim: To investigate work addiction among critical care nurses' and its relationship with their creativity and professional quality of life. Methods: A cross-sectional study was conducted in 4 ICUs at El-Menshawy General Hospital in Elgarbia, Egypt. All nurses were invited to complete a survey in Google Forms that included the Dutch Work Addiction Scale, Nurses Creativity Questionnaire, and Professional Quality of Life Scale. Results: A total of 242 intensive care nurses participated in the study: Pediatric (82), Medical (92), Neurological (30), and Cardiac (38). This study revealed that higher levels of work addiction in nurses were associated with increased creativity (r=0.311, p<0.001) and improved professional quality of life (r=0.574, p<0.001). Also, more than half (53.7%) of critical nurses had moderate levels of work addiction and just under half (49.3%) also had a moderate level of creativity and professional quality of life. Statistically significant differences were found between critical care nurses' levels of work addiction, creativity, and professional quality of life (p=0.001). Multiple regression analyses indicated that work addiction and other parameters significantly predicted nurses' creativity (R2=0.453, p<0.001). Specifically, work addiction (B=0.606, p<0.001), compassion satisfaction (B=0.692, p<0.001), burnout (B=0.438, p<0.001), and secondary traumatic stress (B=0.199, p=0.025) were significant predictors of creativity. Additionally, attributes related to work addiction and other parameters significantly predicted professional quality of life (R2=0.467, p<0.001). Sensitivity toward problems (B=0.874, p<0.001) and risk-taking (B=2.098, p<0.001) were attributes that improved professional quality of life.