Abstract: Back ground: intensive care unit nurses should be able to perform liver graft assessment post liver transplantation and learn principle of care to identify and manage any problem during ICU staying. Aim: this research was carried out to investigate the effect of implementing nursing care of patients post liver transplantation on nurses performance. Study design: Quasi-experimental research design was utilized in this study. Setting: intensive care unit at Alrajhey liver hospital at Assiut University hospitals. Sample: A convenience sample of all available nurses. The sample size was 30 nurses. Tools: Utilizing two tools, Nurse's knowledge questionnaire and Observational checklist. Results: Finding of the present study revealed that significant statistically correlation between total nurses’ knowledge and skills regarding assessment of liver graft function and intensive care post liver transplantation which indicated positive relation between knowledge and skills. Finding of the present study revealed that insignificant relationship between information and skills regarding assessment of liver graft function and intensive care post liver transplantation and their socio - demographic data. Conclusion: Nurses` knowledge and practice regarding assessment of liver graft function in ICU and becomes to the satisfactory level after the educational program. Recommendation: Nurses need for continuous training programs to increase their performance regarding assessment of liver graft function post liver transplantation.