Abstract: Pressure controlled-volume guaranteed mode combines the benefits of both pressure controlled ventilation and pressure controlled ventilation modes for the mechanically ventilated patients in ICUs Aim: is to assess weaning outcomes of the mechanically ventilated patient after using Pressure controlled ventilation-volume guaranteed and synchronized intermittent mandatory ventilation mode Design: A quasi-experimental research design. Setting: General intensive care unit at Assuit university hospital. Patients and methods: Purposive sample of 80 patients who were intubated for >24 hrs, divided into two groups equally, study group (PCV-VG group) and control group (SIMV-VC group). Pressure controlled ventilation-volume guaranteed mode was selected for study group and control group patients was mechanically ventilated on synchronized intermittent mandatory ventilation  mode Tool I : Patient assessment Tool II: Mechanical ventilator parameters assessment Tool III: Weaning outcomes assessment Results: Concerning weaning outcomes; 57% of SIMV-VC  group experienced weaning failure versus 35% in PCVG group, more than half of SIMV group re-intubated versus one third in PCVG group and less duration of mechanical ventilation for PCVG group versus SIMV group. Conclusion: Pressure controlled-volume guaranteed mode was more effective than synchronized intermittent mandatory ventilation mode in improving weaning outcomes Recommendations: Provide ICU nurses an educational program about Pressure controlled volume guaranteed and nursing care to improve waning outcomes.

This study aimed to evaluate the impact of specifically designed nursing guidelines on the knowledge and practical skills of nurses caring for patients with burn injuries. A quasi-experimental design with pre-test and post-test assessments was employed. The study was conducted in the burn unit of a Main University Hospital in Egypt. A convenience sample of 20 nurses of various ages and both genders participated. Data were collected using two tools:(I) a structured interview questionnaire to assess demographic data and knowledge, and an observational checklist to evaluate practices; and (II) the Designed Nursing Care Guidelines for Burn Patients (a booklet). The intervention involved the implementation of these guidelines. Following the intervention, a significant improvement was observed in both nurses' knowledge and practical skills. The rate of correct knowledge answers increased from a pre-test mean of 72% to a post-test mean of 89%. The percentage of correctly performed practical tasks rose from 11% to 25%. The most substantial improvements were noted among younger nurses (20-30 years) and those holding a bachelor's degree. Furthermore, nurses with 5-10 years of experience in the burn unit demonstrated the highest overall levels of knowledge and practice post-intervention. The designed nursing guidelines were effective in significantly enhancing both the knowledge and practical skills of nurses providing burn care. To sustain and build upon these improvements, a commitment to continuous education and the standardized use of evidence-based protocols is essential. We recommend the establishment of regular training.

Background: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is recently identified systemic autoinflammatory disease that manifests in adults and has a high morbidity and mortality rate. Aim: to evaluate the effect of implementing an educational program regarding vacuoles, E1-enzyme, X-linked, auto-inflammatory and somatic syndrome on nurses' knowledge in intensive care units. Design: quasi-experimental research design was utilized. Setting: The study was accomplished at the Sohag Main University Hospital, in Critical Care and General ICU. Subjects: Convenient samples of 70 nurses were recruited from general and critical care ICUs Tool I: Structured Interview Questionnaire Assessment Included Nurses’ Demographic Data. Tool II: Nurses’ Knowledge Pre-Post Educational Program Assessment. Results: the mean knowledge score was 7.31±4.1 in the pre-test versus 18 ±1.7 in the post test with high statistically significant difference and about 6% of nurses had satisfactory knowledge level in pretest versus 84% of them after implementation of educational program. Conclusion: After the educational program was put into place, the majority of nurses in the study group had a good level of knowledge, and their overall mean scores significantly improved Recommendation: The current study should be replicated on larger probability samples. Key words: Auto-Inflammatory, Educational Program, E1-Enzyme, Intensive Care Units, Nurses' Knowledge, Somatic Syndrome, Vacuoles, X-Linked.