Background: Self-efficacy is directly changeable, can predicts improvement in head nurse's performance. Aim: Determine the effect of self-efficacy educational program on head nurse's performance. Study design: A quasi-experimental design was used. Setting: The study was conducted at Assiut University Main Hospital. Subject: Consisted of 44 head nurses.  Tools: three tools were used to collect data: First tool; Self-administered questionnaire sheet including:-a): Personal data sheet; gathers data about: gender, age, years of experience, educational qualifications, and marital status, and b): Self – efficacy assessment scale. Second tool; Performance checklist, and third tool; Program evaluation sheet including a): Head nurse's knowledge test. b): Head nurse's opinionnier sheet.  Results: The study revealed that head nurses had unsatisfactory knowledge level about self-efficacy in preprogram assessment but satisfactory in immediately post and follow up phase of the program implementation (90.9%, and 81.8%) respectively. The highest percentages of head nurses have low self-efficacy in preprogram assessment(81.8%), but high self-efficacy in immediate post and follow up phase(86.3%, 81.8%) respectively. Conclusion: There was positive correlation between self-efficacy and total performance categories with statistical significant relation. Recommendations: Further training for physicians, nurses and nursing administrators and update faculty curriculum to include self-efficacy in the undergraduate courses.